GROUP LEADERDr. Fábio Fernandes
Assistant Professor,
Department of Bioengineering
Instituto Superior Técnico


While the most basic function of Biomembranes is compartmentalization, they play significantly more complex roles in cellular signalling. The organization of their lipid and protein components is of critical importance for regulation of these signalling events. Despite this recognized importance, the current understanding of biomembrane organization at the molecular level is rudimentary, given the difficulties in studying these extraordinarily complex and highly dynamic structures.

Our lab employs a combination of Advanced Fluorescence Microscopy and Spectroscopy tools and our team has extensive expertise on the development and application of these tools in Membrane Biophysics and Cellular Biology. These complementary tools allow us to characterize biomembrane structure at both nano- and micro-scale at high temporal resolution.
Phosphatidylinositol 4,5- bisphosphate

Functional lipidsPhosphatidylinositol 4,5- bisphosphate

Characterization of the lateral organization of the key phospholipid PI(4,5)P2
Engineering of Exosomes

ExosomesEngineering of Exosomes

Modification of exosomes towards therapeutic applications
Development of Fluorescence Microscopy Tools in Membrane Biophysics

Fluorescence MicroscopyDevelopment of Fluorescence Microscopy Tools in Membrane Biophysics